Sesamoiditis manifests as pain and inflammation in the sesamoid bones, which are small, round bones located under the big toe joint. This condition typically results from excessive pressure or repetitive stress on the ball of the foot, causing discomfort directly beneath the big toe. Patients often experience sharp or throbbing pain that worsens with activities like walking, running, or wearing tight or high-heeled shoes. 

The pain can make it difficult to engage in physical activities or even to walk comfortably, as the pressure on the sesamoid bones during each step exacerbates the symptoms. In addition to pain, there may be swelling and tenderness in the area. Treatment usually involves rest, ice application, and adjustments to footwear to reduce pressure on the affected area. Orthotic devices may also be recommended to provide additional support and relieve stress on the sesamoid bones. In severe cases, when conservative measures are not effective, further interventions such as corticosteroid injections or surgical options may be considered.